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A complete of three % of Energetic compound is excreted in urine as unchanged Energetic substance. Tapentadol is Moreover metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and to hydroxy tapentadol (2 %) by CYP2D6, that happen to be even more metabolised by conjugation. Consequently, Lively substance metabolism mediated by cytochro